Keratin 8(ab-74) antibody detects endogenous level of total keratin 8 protein welcome login register message board published papers. Full-text paper (pdf): keratin 8 phosphorylation by protein kinase c regulates shear stress-mediated disassembly of keratin intermediate filaments in alveolar epithelial cells. Protein sequence alignment of human keratin 1, 2a, 3,4, 5, 6a, 7, and 8 (krt1 – krt8) only the first rod domain is shown above alignment was created using clustal omega . Liver injury/regeneration human keratin 8 variants promote mouse acetaminophen hepatotoxicity coupled with c-jun amino-terminal kinase activation and protein adduct formation.
[tags: function, structure, cohesive, protein] better essays 626 words | (18 pages) involved in the immune system and the water-insoluble keratin of hair, hooves . Complete information for krt8 gene (protein coding), keratin 8, including: function, proteins, disorders, pathways, orthologs, and expression genecards - the human gene compendium. Keratin 8 proteins (krt8) krt8 is a member of the type ii keratin family clustered on the long arm of chromosome 12 additionally we are shipping keratin 8 antibodies (1005) and keratin 8 kits (19) and many more products for this protein.
Keratin, type i cytoskeletal 8 also known as cytokeratin-8 (ck-8) or keratin-8 (k8) is a keratin protein that in human is encoded by the krt8 gene it is often paired with keratin 18 antibodies to ck8 (eg cam 52) can be used to differentiate lobular carcinoma of the breast from ductal carcinoma of the breast. Elevated keratin-8 (krt8) protein expression is an established diagnostic cancer biomarker in several epithelial cancers (but not atc) several keratins, including krt8, have been suggested to have a role in cell biology beyond that of structural cytoskeletal proteins. Keratin 8 phosphorylation by protein kinase c regulates shear stress-mediated disassembly of keratin intermediate filaments in alveolar epithelial cells.
Learn more about keratin 8 mutations prevent production of any functional vhl protein or the luminal cells show positive staining with keratin (cam52 . Krt8 - keratin 8 mus musculus the intermediate filament protein keratin 8 (k8) is critical for the development of most mouse embryos beyond midgestation . Anti-keratin 8 antibody detects endogenous levels of total keratin 8 protein validated for wb, ihc, if, and elisa. Papers in press papers of the week keratin 8 phosphorylation by protein kinase c δ regulates shear stress-mediated disassembly of keratin intermediate filaments . The gene k8 (keratin 8) is mapped to human chromosome 12q1313 it belongs to the type b (basic) subfamily of high molecular weight keratins and exists in combination with keratin 18 the protein has an amino-terminal head, a conserved α-helical central rod domain and a carboxyl-terminal tail domain.
Protein accounts for about three-fourths of the dry matter in human keratin is completely insoluble in water its many better essays 978 words (28 pages). Keratin 8 phosphorylation by protein kinase c δ regulates shear stress-mediated disassembly of keratin intermediate filaments in alveolar epithelial cells . Journal of ovarian research 2016 9:8 for example, are composed of keratin type ii cytoskeletal 8 protein and type i cytoskeletal 18 protein papers, zotero, . Keratin found in: keratin 4, human krt34-gst fusion protein, human krt19-gst fusion protein, human krt40-gst fusion protein, keratin 2, keratin 34, keratin. Keratin is the key component of our skin, hair and nails its protein building blocks have amino acid chains, coiled, cross-linked and classified as either hard or soft it separates us from our environment by forming thin, flexible skin, strong hair and rigid nails.
Keratin 8/18 modulation of protein kinase c-mediated integrin-dependent adhesion and migration of liver epithelial cells this is the final version - click for previous version françois bordeleau. Short communication effects of cerulein on keratin 8 phosphorylation and perinuclear reorganization in pancreatic cancer cells: involvement of downregulation of protein phosphatase 2a and alpha4. Posed of keratin type ii cytoskeletal 8 protein and type i cytoskeletal 18 protein originally named for their mech-anical stability, k8/18 filaments are “stress .
Keratin 8 (hgnc symbol) this protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular . Anti-keratin 8 antibody detects endogenous levels of total keratin 8 protein physical form rabbit igg in phosphate buffered saline (without mg2+ and ca2+), ph 74, 150mm nacl, 002% sodium azide and 50% glycerol. 353 forced overexpression of keratin 8 in primary hepatocytes szabo et al, 2015 ) transfected hepatocytes are analyzed regarding their keratin distribution pattern by immunofluorescence microscopy. Human keratin 8 variants promote mouse acetaminophen hepatotoxicity coupled with c‐jun amino‐terminal kinase activation and protein adduct formation.
In this study, we demonstrate that shear stress, but not stretch, causes disassembly of keratin if in lung alveolar epithelial cells (aec) and that this disassembly is regulated by protein kinase c δ-mediated phosphorylation of keratin 8 (k8) ser-73. Rabbit polyclonal keratin 8 antibody 100% bioguaranteed anti-keratin 8 antibody detects endogenous levels of total keratin 8 protein peer-reviewed papers 15. Keratin k78 (k5b): k78 has a mw of 568 kda and an isoelectric ph of 58 its protein chain contains 520 amino acids) the mrna encoding k78 is produced in the cells of the epithelial covering of the human tongue ( rogers et al 2005 ).